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Alectinib

ALK (Anaplastic Lymphoma Kinase) inhibitor

MECHANISM OF ACTION

MECHANISM OF KIDNEY INJURY

Potential direct tubular injury

CLINICAL KIDNEY SYNDROME

Acute Kidney Injury

CARDIOVASCULAR ADVERSE EFFECTS

LYTE ABNORMALITIES

Elevation in serum Creatinine.

RISK FACTORS

MITIGATION STRATEGIES

SUGGESTIONS 

NOTES/COMMENTS

PHARMACOKINETICS

Molecular Weight

Volume of Distribution

Plasma Protein Binding

Metabolism

Bioavailability

Half-life elimination

Time to peak

Excretion

Dialyzable?

REF:

PATHOLOGY SLIDES:

ENTRY UPDATES:

Mohamed Ibrahim

USA

Nov 7, 2024

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