Amphotericin B

Polyene Anti-fungal Agent.

MECHANISM OF ACTION

Attacks fungi by binding to ergosterol in their cell membranes, creating pores, disrupting membrane integrity, and causing leakage, ultimately leading to cell death

MECHANISM OF KIDNEY INJURY

Direct tubular injury

CLINICAL KIDNEY SYNDROME

AKI

CARDIOVASCULAR ADVERSE EFFECTS

LYTE ABNORMALITIES

Hypokalemia, Hypomagnesemia related to tubular damage.

RISK FACTORS

Volume depletion, concomitant use of nephrotoxic agents.

MITIGATION STRATEGIES

Using lipid formulas. Adequate volume repletion.

SUGGESTIONS

NOTES/COMMENTS

PHARMACOKINETICS

Molecular Weight

Volume of Distribution

Plasma Protein Binding

Metabolism

Bioavailability

Half-life elimination

Time to peak

Excretion

Dialyzable?

REF:

PATHOLOGY SLIDES:

ENTRY UPDATES:

Mohamed Ibrahim

USA

Nov 7, 2024

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